Elastic network models proved to be powerful tools for exploring the collective dynamics of biomolecular systems in the last two decades. Numerous examples demonstrate their applicability to a broad range of phenomena, from allosteric transitions, to modeling protein-substrate interactions key to regulation and signaling events, to supramolecular machinery. Recent advances in cryo-EM characterizaton of big structures as well as genome-scale identification of 3D contacts between gene loci now open the way to a new level of applications, including the exploration of the 3D structural dynamics of the chromosomes, with the help of elastic network models, further supporting their utility as a tool applicable across multiple scales, from molecules to genome-wide associations.